REVERT
Shin D, Gong JR, Jeong SD, Cho Y, Kim HP, Kim TY, Cho KH
2025 · Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A cell fate change such as tumorigenesis incurs critical transition.
Abstract
From the original paper, Advanced science (Weinheim, Baden-Wurttemberg, Germany) · PubMed
A cell fate change such as tumorigenesis incurs critical transition. It remains a longstanding challenge whether the underlying mechanism can be unraveled and a molecular switch that can reverse such transition is found. Here a systems framework, REVERT, is presented with which can reconstruct the core molecular regulatory network model and a reversion switch based on single-cell transcriptome data over the transition process is identified. The usefulness of REVERT is demonstrated by applying it to single-cell transcriptome of patient-derived matched organoids of colon cancer and normal colon. REVERT is a generic framework that can be applied to investigate various cell fate transition phenomena.
Summary
Editorial summary pending review by the maintainer. The paper's own abstract appears above; the Atlas summary in the maintainer's voice will explain how REVERT relates to the cross-modality inverse-design framework of the review.
Why this class
Level 3 because candidate interventions enter an explicit forward operator and the predicted post-intervention outcome is what scores each candidate. Representation family is executable intervention model. Cited in §3.4 of the review. Editorial rationale pending review by the maintainer.