L0 · Target-feature discovery
Inverse design fidelity
Level 0 · Target-feature discovery
Uses the target state to identify characteristic factors or features; no source-to-target intervention model.
Methods at this level
5 methods
Sorted by publication year, oldest first.
D'Alessio et al. · 2015 · Stem Cell Reports
Classical Level 0 exemplar. Identifies TFs specifically enriched in a target cell type against a broad background of other lineages.
T
No code Repro 0/4
Okawa S et al. · 2019 · Nucleic acids research
Advances in single-cell RNA-sequencing techniques reveal the existence of distinct cell subpopulations.
T
Code Repro 3/4 FAIR 0/5
TransSynW
L0Ribeiro MM et al. · 2020 · Stem cells translational medicine
Generation of desired cell types by cell conversion remains a challenge.
D T
Code Repro 4/4 FAIR 0/5
Appleton E et al. · 2025 · Cell reports
The creation of induced pluripotent stem cells (iPSCs) has enabled scientists to explore the function, mechanisms, and differentiation processes of many types of cells.
D
Code Repro 3/4 FAIR 0/5
REPROcode
L0Kurochkin I et al. · 2026 · Cell systems
Direct reprogramming of immune cells holds promise for immunotherapy but is constrained by limited knowledge of transcription factor (TF) networks.
T
No code Repro 4/4 FAIR 3/5
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